Human C-type Lectin Domain Family 4 Member D, CLEC4D ELISA Kit

SKU: E5133Hu

Size:96 Tests-1 Kit

Background:Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: recognizes damage-associated molecular patterns (DAMPs) of pathogen-associated molecular patterns (PAMPs) of bacteria and fungi (PubMed:23602766, PubMed:23911656). The PAMPs include alpha-mannans on C.albicans hypheas and mycobacterial trehalose 6,6'-dimycolate (TDM) (PubMed:23602766, PubMed:23911656). Interacts with signaling adapter Fc receptor gamma chain/FCER1G, likely via CLEC4E, to form a functional complex in myeloid cells (By similarity). Binding of mycobacterial TDM or C.albicans alpha-mannans to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes (PubMed:23602766, PubMed:23911656). The heterodimer formed with CLEC6A is active against fungal infection (PubMed:23911656). Functions as an endocytic receptor (PubMed:14971047). May be involved in antigen uptake at the site of infection, either for clearance of the antigen, or for processing and further presentation to T-cells (PubMed:14971047).

Research_area:Immunology

Applications:ELISA

Target_protein:CLEC4D

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.028μg/mL

Detection range:0.05-20ug/mL

Sample type:Serum, plasma or other biological fluids

Full product name:C-type lectin domain family 4 member D

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q8WXI8

MASS(Da):24,704

GeneID:338339

Synonyms:CD antigen CD368;CD368;CLEC4D;CLEC6;CLEC-6;CLECSF8;C-type lectin domain family 4 member D;C-type lectin superfamily member 8;C-type lectin-like receptor 6;MCL;MPCL

Gene names:CLEC4D

Standard solution:24μg/mL