Human Bile Salt Export Pump, ABCB11 ELISA Kit

SKU: E6558Hu

Size:96 Tests-1 Kit

Background:Catalyzes the transport of the major hydrophobic bile salts, such as taurine and glycine-conjugated cholic acid across the canalicular membrane of hepatocytes in an ATP-dependent manner, therefore participates to hepatic bile acids homeostasis and consequently to lipid homeostasis through regulation of biliary lipid secretion in a bile salts dependent manner (PubMed:16332456, PubMed:22262466, PubMed:15791618, PubMed:18985798, PubMed:19228692, PubMed:20398791, PubMed:24711118, PubMed:29507376, PubMed:20010382, PubMed:32203132). Transports taurine-conjugated bile salts more rapidly than glycine-conjugated bile salts (PubMed:16332456). Also transports non-bile acid compounds, such as pravastatin and fexofenadine in an ATP-dependent manner and may be involved in their biliary excretion (PubMed:15901796, PubMed:18245269).

Research_area:Signal Transduction; Cancer; Metabolism

Applications:ELISA

Target_protein:ABCB11

Reactivity:Human

Assay type:Sandwich

Sensitivity:9.52ng/L

Detection range:20-4500ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Bile salt export pump

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O95342

MASS(Da):146,407

GeneID:8647

Synonyms:ABC16;ABCB11;ATP-binding cassette sub-family B member 11;Bile salt export pump;BRIC2;BSEP;PFIC2;PGY4;SPGP;

Gene names:ABCB11

Standard solution:4800ng/L