Human Atp-binding Cassette Sub-family A Member 3, ABCA3 ELISA Kit

SKU: E3037Hu

Size:96 Tests-1 Kit

Background:Catalyzes the ATP-dependent transport of phospholipids such as phosphatidylcholine and phosphoglycerol from the cytoplasm into the lumen side of lamellar bodies, in turn participates in the lamellar bodies biogenesis and homeostasis of pulmonary surfactant (PubMed: 16959783, PubMed: 17574245, PubMed: 28887056, PubMed: 31473345, PubMed: 27177387). Transports preferentially phosphatidylcholine containing short acyl chains (PubMed: 27177387). In addition plays a role as an efflux transporter of miltefosine across macrophage membranes and free cholesterol (FC) through intralumenal vesicles by removing FC from the cell as a component of surfactant and protects cells from free cholesterol toxicity (PubMed: 26903515, PubMed: 25817392, PubMed: 27177387).

Research_area:Signal Transduction

Applications:ELISA

Target_protein:ABCA3

Reactivity:Human

Assay type:Sandwich

Sensitivity:10.03ng/L

Detection range:20-3800ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Atp-Binding Cassette Sub-Family A Member 3

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q99758

MASS(Da):191,362

GeneID:21

Synonyms:ABCA 3;ABCA3;ABC-C transporter;ATP-binding cassette 3;ATP-binding cassette sub-family A member 3;ATP-binding cassette transporter 3

Gene names:ABCA3

Standard solution:4000ng/L