Human Adenosine Deaminase, ADA ELISA Kit

SKU: E0777Hu

Size:96 Tests-1 Kit

Background:Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine (PubMed: 8452534, PubMed: 16670267). Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4 (PubMed: 20959412). Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion (PubMed: 11772392). Enhances dendritic cell immunogenicity by affecting dendritic cell costimulatory molecule expression and cytokines and chemokines secretion (By similarity). Enhances CD4+ T-cell differentiation and proliferation (PubMed: 20959412). Acts as a positive modulator of adenosine receptors ADORA1 and ADORA2A, by enhancing their ligand affinity via conformational change (PubMed: 23193172). Stimulates plasminogen activation (PubMed: 15016824). Plays a role in male fertility (PubMed: 21919946, PubMed: 26166670). Plays a protective role in early postimplantation embryonic development (By similarity).

Research_area:Epigenetics and Nuclear Signaling

Applications:ELISA

Target_protein:ADA

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.05ng/ml

Detection range:0.1-40.ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Adenosine Deaminase

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P00813

MASS(Da):40,764

GeneID:100

Synonyms:ADA;Adenosine aminohydrolase;Adenosine deaminase

Gene names:ADA

Standard solution:48ng/ml