Human A2M/Alpha 2-Macroglobulin ELISA Kit PicoKine®

SKU: EK1118

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: A2M

Specificity: Natural human A2M

Background: Alpha-2-macroglobulin, also known as A2M or CPAMD5 is a large plasma protein found in the blood. This gene is mapped to 12p13.31. Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. This gene is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.

Immunogen: Target protein isolated from human plasma

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Reference:

Uniprot ID: P01023

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 2

Protein Name: Alpha-2-macroglobulin

Gene Full Name: alpha-2-macroglobulin

Synonyms: A2M; Alpha 2 M; alpha 2 macroglobulin; CPAMD5; FWP007; S863 7; α-2M