Human 5-Hydroxytryptamine Receptor 2A, HTR2A ELISA Kit

SKU: E6733Hu

Size:96 Tests-1 Kit

Background:G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed: 1330647, PubMed: 18703043, PubMed: 19057895). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD) (PubMed: 28129538). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors (PubMed: 28129538). Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways (PubMed: 28129538). Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores (PubMed: 18703043, PubMed: 28129538). Affects neural activity, perception, cognition and mood (PubMed: 18297054). Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction. (Microbial infection) Acts as a receptor for human JC polyomavirus/JCPyV.

Research_area:Neuroscience

Applications:ELISA

Target_protein:HTR2A

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.019ng/ml

Detection range:0.05-10ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:5-Hydroxytryptamine Receptor 2A

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P28223

MASS(Da):52,603

GeneID:3356

Synonyms:5-HT-2;5-HT-2A;5-hydroxytryptamine receptor 2A;HTR2A;Serotonin receptor 2A

Gene names:HTR2A

Standard solution:12.8ng/ml