HMBS Antibody - Cat. #: CSB-RA998378A0HU

SKU: CSB-RA998378A0HU

Size :50ul

Clone Number:8G12

Aliases:Porphobilinogen deaminase (PBG-D) (EC 2.5.1.61) (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase), HMBS, PBGD UPS

Product Type:Recombinant Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P08397

Immunogen:A synthesized peptide derived from human HMBS

Raised in:

Species Reactivity:Human

Tested Applications:ELISA, WB; Recommended dilution: WB:1:500-1:2000

Background:As part of the heme biosynthetic pathway, catalyzes the sequential polymerization of four molecules of porphobilinogen to form hydroxymethylbilane, also known as preuroporphyrinogen (PubMed:18936296, PubMed:19138865, PubMed:23815679). Catalysis begins with the assembly of the dipyrromethane cofactor by the apoenzyme from two molecules of porphobilinogen or from preuroporphyrinogen. The covalently linked cofactor acts as a primer, around which the tetrapyrrole product is assembled. In the last step of catalysis, the product, preuroporphyrinogen, is released, leaving the cofactor bound to the holodeaminase intact (PubMed:18936296). {ECO:0000269|PubMed:18936296, ECO:0000269|PubMed:19138865, ECO:0000269|PubMed:23815679}.

Clonality:Monoclonal

Isotype:Rabbit IgG

Purification Method:Affinity-chromatography

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:HMBS

Research Areas:Cell biology; Metabolism; Signal transduction