HLA-DPB1 Monoclonal Antibody

SKU: BT-MCA3372

Size:100μL

Background:HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.

Research_area:Others

Target_protein:HLA-DPB1

applications:IHC, FCM

Reactivity:Human, Rat

Clonality:Monoclonal

Clone ID:5C9F4

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:HLA-DPB1

Immunogen:Purified recombinant fragment of human HLA-DPB1 (AA: extra 30-215) expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Purified antibody in PBS with 0.05% sodium azide

Concentration:

Molecular weight(Da):29.2kDa

UniProt accession:P04440

Synonyms:DPB1, HLA-DP, HLA-DPB, HLA-DP1B

GeneID:3115