Histone H2B Monoclonal Antibody

SKU: E-AB-22086

Size: 200μL

Storage: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping: The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date: 12 months

Category ID_II: Primary Antibodies

Category ID_III: Monoclonal Antibodies

Abbreviation: Histone H2B

Target Synonym: HIST1H2BA;testis;bA317E16.3;H2B;H2B histone family member U;H2B histone family member U testis specific;H2B histone family;member U;(testis specific);H2B testis;H2B1A;H2BFU;H2BT;HIST1H2BA;Histone 1;H2ba;Histone cluster 1 H2ba;Histone H2B;Histone H2B testis;Histone H2B type 1 A;Histone H2B type 1-A;Histone H2B type 1A;STBP;Testis specific histone H2B;Testis-specific histone H2B;TSH 2B;TSH2B;TSH2B.1

Research Areas: Cancer;Epigenetics and Nuclear Signaling

Conjugation: Unconjugated

Host: Mouse

Species reactivity: Human;Mouse;Rat

Application: WB;IF

Isotype: IgG

Clonality: Monoclonal

Clone NO.: Clone:3C3

UNIProt ID: P33778

Accession:

Background: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. HIST1H2BB (Histone Cluster 1 H2B Family Member B) is a Protein Coding gene. Among its related pathways are DNA Double-Strand Break Repair and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. GO annotations related to this gene include sequence-specific DNA binding and protein heterodimerization activity. An important paralog of this gene is HIST1H2BN.

Concentration: 1 mg/mL

Immunogen: Synthetic Peptide

Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.4.

Purification method: Protein A purification

Dilution: WB 1:1000-3000;IF 1:100-200

Calculated MW: 14kDa

ObservedMW: 14kDa