HIPK3 Polyclonal Antibody

SKU: E-AB-19326

Size: 200μL

Storage: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping: The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date: 12 months

Category ID_II: Primary Antibodies

Category ID_III: Polyclonal Antibodies

Abbreviation: HIPK3

Target Synonym: Androgen receptor interacting nuclear protein kinase;Androgen receptor-interacting nuclear protein kinase;ANPK;DYRK6;Fas interacting serine/threonine protein kinase;Fas-interacting serine/threonine-protein kinase;FIST;FIST3;Hipk3;HIPK3;homeodomain interacting protein kinase 3;Homeodomain-interacting protein kinase 3;Homolog of protein kinase YAK1;PKY;RP24 297H17.5;YAK1

Research Areas: Cancer;Cell Biology;Epigenetics and Nuclear Signaling;Signal transduction

Conjugation: Unconjugated

Host: Rabbit

Species reactivity: Human;Mouse;Rat

Application: IHC

Isotype: IgG

Clonality: Polyclonal

Clone NO.:

UNIProt ID: Q9H422

Accession:

Background: Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphorylates RUNX2 that synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE).

Concentration: 0.6 mg/mL

Immunogen: Synthetic peptide of human HIPK3

Buffer: PBS with 0.05% NaN3 and 40% Glycerol,pH7.4

Purification method: Antigen affinity purification

Dilution: IHC 1:50-1:300

Calculated MW:

ObservedMW: