HDAC1 Antibody - Cat. #: CSB-PA157026

SKU: CSB-PA157026

Size :100ul

Clone Number:

Aliases:DKFZp686H12203 antibody; GON 10 antibody; HD1 antibody; HDAC 1 antibody; HDAC1 antibody; HDAC1_HUMAN antibody; Histone deacetylase 1 antibody; Reduced potassium dependency yeast homolog like 1 antibody; RPD3 antibody; RPD3L1 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q13547

Immunogen:Synthesized peptide derived from Human HDAC1.

Raised in:Rabbit

Species Reactivity:Human, Mouse, Rat

Tested Applications:ELISA, WB, IHC; WB:1:500-1:3000, IHC:1:50-1:100

Background:Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Component a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity. Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer.

Richard L. Cai, J. Biol. Chem., Sep 2000; 275: 27909.
Takayoshi Matsumura, J. Biol. Chem., Apr 2005; 280: 12123 - 12129.
Gregory David, J. Biol. Chem., Jun 2002; 277: 23658 - 23663.
Yuh-Long Chang, PNAS, Aug 2001; 98: 9730.

Clonality:Polyclonal

Isotype:IgG

Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:HDAC1

Research Areas:Isotype/Loading Controls;Epigenetics and Nuclear Signaling;Cardiovascular;Stem cells