GPX2 Rabbit Polyclonal Antibody

SKU: BT-AP10272

Size:100μL

Background:The protein encoded by this gene belongs to the glutathione peroxidase family| members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione| and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates| which vary in cellular location and substrate specificity. This isozyme is predominantly expressed in the gastrointestinal tract (also in liver in human)| is localized in the cytoplasm| and whose preferred substrate is hydrogen peroxide. Overexpression of this gene is associated with increased differentiation and proliferation in colorectal cancer. This isozyme is also a selenoprotein| containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon| which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure| designated the Sec insertion sequence (SECIS) element| that is necessary for the recognition of UGA as a Sec codon| rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene.

Research_area:Cell biology; Metabolism

Target_protein:GPX2

applications:WB

Reactivity:Human, Mouse, Rat

Clonality:Polyclonal

Clone ID:

Host:Rabbit

Isotype:IgG

Gene Symbol/ Name:GPX2

Immunogen:The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage:-20°C for 1 year

Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration:1 mg/ml

Molecular weight(Da):20900

UniProt accession:Human: P18283; Mouse: Q9JHC0; Rat: P83645

Synonyms:GPX2

GeneID:Human: 2877; Mouse: 14776