FZD1 Antibody, HRP conjugated - Cat. #: CSB-PA891570LB01HU

SKU: CSB-PA891570LB01HU

Size :50ug

Clone Number:

Aliases:Chfz-1 antibody; Dfrizzled-1 antibody; DKFZp564G072 antibody; FLJ95923 antibody; Frizzled 1 antibody; Frizzled homolog 1 (Drosophila) antibody; Frizzled homolog 1 antibody; Frizzled-1 antibody; Fz receptor 1 antibody; Fz-1 antibody; Fz1 antibody; FZD1 antibody; FZD1_HUMAN antibody; FzE1 antibody; hFz1 antibody; Rfz1 antibody; Wnt receptor antibody; Xfrizzled-1 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q9UP38

Immunogen:Recombinant Human Frizzled-1 protein (73-322AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA

Background:Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activated by Wnt3A, Wnt3, Wnt1 and to a lesser extent Wnt2, but not by Wnt4, Wnt5A, Wnt5B, Wnt6, Wnt7A or Wnt7B.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:HRP

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:FZD1

Research Areas:Cancer; Signal transduction; Stem cells