FoxO4 (Acetyl Lys407) Rabbit Polyclonal Antibody

SKU: BT-AP02726

Size:100μL

Background:disease:A chromosomal aberration involving FOXO4 is found in acute leukemias. Translocation t(X;11)(q13;q23) with MLL/HRX. The result is a rogue activator protein.|Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle.|pharmaceutical:A constitutively active FOXO4 mutant where phosphorylation sites Thr-32| Ser-187 and Ser-262 have been mutated to alanine may have therapeutic potential in ERBB2/HER2-overexpressing cancers as it inhibits ERBB2-mediated cell survival| transformation and tumorigenicity.|PTM:Acetylation by CBP| which is induced by peroxidase stress| inhibits transcriptional activity. Deacetylation by SIRT1 is NAD-dependent and stimulates transcriptional activity.|PTM:Phosphorylation by PKB/AKT1 inhibits transcriptional activity and is responsible for cytoplasmic localization.|Contains 1 fork-head DNA-binding domain.|subcellular location:When phosphorylated| translocated from nucleus to cytoplasm. Dephosphorylation triggers nuclear translocation.|subunit:Interacts with CBP| MYOCD| SIRT1| SRF and YWHAZ. Acetylated by CBP and deacetylated by SIRT1. Binding of YWHAZ inhibits DNA-binding.|tissue specificity:Heart| brain| placenta| lung| liver| skeletal muscle| kidney and pancreas. Isoform zeta is most abundant in the liver| kidney| and pancreas.|

Research_area:Epigenetics and nuclear signaling

Target_protein:FOXO4

applications:WB, ELISA

Reactivity:Human, Mouse

Clonality:Polyclonal

Clone ID:

Host:Rabbit

Isotype:IgG

Gene Symbol/ Name:FoxO4

Immunogen:The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage:-20°C for 1 year

Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration:1 mg/ml

Molecular weight(Da):55550

UniProt accession:Human: P98177; Mouse: Q9WVH3

Synonyms:FoxO4 ;Acetyl Lys407; Forkhead box protein O4; Fork head domain transcription factor AFX1

GeneID:Human: 4303; Mouse: 54601