FCER2 Monoclonal Antibody

SKU: BT-MCA2047

Size:100μL

Background:The human leukocyte differentiation antigen CD23 (FCE2) is a key molecule for B-cell activation and growth. It is the low-affinity receptor for IgE. The truncated molecule can be secreted, then functioning as a potent mitogenic growth factor.(supplied by OMIM) . It is expressed on most mature, conventional B cells (but not on peritoneal CD5+ B cells), and can also be found on the surface of T cells, macrophages, platelets and EBV transformed B lymphoblasts. Expression of CD23 has been detected in neoplastic cells from cases of B cell chronic Lymphocytic leukemia. CD23 is expressed by B cells in the follicular mantle but not by proliferating germinal centre cells. CD23 is also expressed by eosinophils. CD23 is distinct from the high affinity IgE receptors found on basophils and mast cells, which mediate allergic reactions. The low affinity receptors are thought to play a role in isotype specific immunoregulation. The regulation of CD23 surface expression appears to be integral with the complex IgE system, which involves interactions of cells, cytokines, antibodies and regulatory factors. CD23 has been described as a

Research_area:Immunology, Stem cells

Target_protein:FCER2

applications:FCM

Reactivity:Human

Clonality:Monoclonal

Clone ID:5B5

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:FCER2

Immunogen:Purified recombinant fragment of human FCER2 expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Ascitic fluid containing 0.03% sodium azide.

Concentration:

Molecular weight(Da):37kDa

UniProt accession:P06734

Synonyms:CD23, FCE2, CD23A, IGEBF, CLEC4J, FCER2

GeneID:2208