EWSR1 Polyclonal Antibody

SKU: E-AB-18995

Size: 200μL

Storage: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping: The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date: 12 months

Category ID_II: Primary Antibodies

Category ID_III: Polyclonal Antibodies

Abbreviation: EWSR1

Target Synonym: bK984G1.4;bK984G1.4 Ewing sarcoma breakpoint region 1 protein;Ewing sarcoma breakpoint region 1;Ewing sarcoma breakpoint region 1 protein;Ewings sarcoma EWS Fli1 type 1 oncogene;EWS;EWS oncogene;EWS RNA binding protein 1;EWS;EWSR 1;Ewsr1;EWSR1 protein;RNA binding protein EWS;RNA-binding protein EWS

Research Areas: Cancer;Epigenetics and Nuclear Signaling;Tags and Cell Markers

Conjugation: Unconjugated

Host: Rabbit

Species reactivity: Human;Mouse

Application: WB;IHC

Isotype: IgG

Clonality: Polyclonal

Clone NO.:

UNIProt ID: Q01844

Accession:

Background: This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11;22)(q24;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14.

Concentration: 1.26 mg/mL

Immunogen: Fusion protein of human EWSR1

Buffer: PBS with 0.05% NaN3 and 40% Glycerol,pH7.4

Purification method: Antigen affinity purification

Dilution: WB 1:1000-1:5000;IHC 1:50-1:300

Calculated MW: 68 kDa

ObservedMW: Refer to figures