ETBR rabbit pAb

SKU: ES8504

Size: 100μL

Source:Rabbit

Applications:WB;IHC;IF;ELISA

Reactivity:Human;Rat;Mouse;

Dilution:IHC-p: 100-300.WB 1:500-2000, ELISA 1:10000-20000

Immunogen:Synthesized peptide derived from ETBR at AA range: 31-80

Storage_stability:-20°C/1 year

Clonality:Polyclonal

Isotype:IgG

Concentration:1 mg/ml

Observed_band(KD):50kD

Human_gene_id:1910

Human_swiss_prot_no:P24530

Subcellular_location:Cell membrane ; Multi-pass membrane protein. internalized after activation by endothelins. .

Other_name:Endothelin B receptor (ET-B;ET-BR;Endothelin receptor non-selective type)

Background:The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Oct 2016],