Estrogen Receptor alpha Polyclonal Antibody

SKU: E-AB-60073

Size::120μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Polyclonal Antibodies

Abbreviation:Estrogen Receptor alpha

Target Synonym:ESR1;ER;ESR;ESRA;ESTRR;Era;NR3A1;ER alpha

Research Areas:Cancer;Epigenetics and Nuclear Signaling;Neuroscience;Signal Transduction

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Mouse

Application:WB

Isotype:IgG

Clonality:Polyclonal

Clone NO.:

UNIProt ID:P03372

Accession:

Background:This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined.

Concentration:1mg/mL

Immunogen:Recombinant fusion protein of human Estrogen Receptor alpha (NP_000116.2).

Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification method:Affinity purification

Dilution:WB 1:1000-1:4000

Calculated MW:35kDa/47kDa/53kDa/66kDa

ObservedMW:75kDa