ERK 5 rabbit pAb

SKU: ES20759

Size: 100μL

Source:Rabbit

Applications:WB;IHC;IF

Reactivity:Human;Mouse;Rat

Dilution:WB: 1:1000-2000 IHC:1:200-500

Immunogen:Recombinant Protein of ERK 5

Storage_stability:-20°C/1 year

Clonality:Polyclonal

Isotype:IgG

Concentration:

Observed_band(KD):89-115kD

Human_gene_id:5598

Human_swiss_prot_no:Q13164

Subcellular_location:Cytoplasm. Nucleus. Nucleus, PML body. Translocates to the nucleus upon activation.

Other_name:MAPK7; BMK1; ERK5; PRKM7; Mitogen-activated protein kinase 7; MAP kinase 7; MAPK 7; Big MAP kinase 1; BMK-1; Extracellular signal-regulated kinase 5; ERK-5

Background:The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor type kinases, and G protein-coupled receptors. In response to extracelluar signals, this kinase translocates to cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported. [provided by RefSeq, Jul 2008],