ErbB-2/HER-2 Mouse mAb

SKU: EM1079

Size: 100μL

Source:Mouse

Applications:WB, IHC

Reactivity:Human

Dilution:WB 1:1,000 IHC 1:200-500

Immunogen:Synthetic Peptide

Storage_stability:PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

Clonality:Monoclonal

Isotype:IgG1

Concentration:1mg/mL

Observed_band(KD):138kDa

Human_gene_id:2064

Human_swiss_prot_no:P04626

Subcellular_location:Cytoplasm. Nucleus and Cell membrane

Other_name:CD340, HER 2/neu, HER2, MLN 19, MLN19, NEU, NGL, p185, p185erbB2, Proto oncogene c ErbB 2, Proto oncogene Neu, TKR1

Background:ErbB 2 is a receptor tyrosine kinase of the ErbB 2 family. It is closely related instructure to the epidermal growth factor receptor. ErbB 2 oncoprotein is detectable in a proportion of breast and other adenocarconomas, as well as transitional cell carcinomas. In the case of breast cancer, expression determined by immunohistochemistry has been shown to be associated with poor prognosis.