EPHB2 Antibody - Cat. #: CSB-PA945346

SKU: CSB-PA945346

Size :100ul

Clone Number:

Aliases:cek5 antibody; Developmentally regulated EPH related tyrosine kinase antibody; DRT antibody; EK5 antibody; ELK related protein tyrosine kinase antibody; Eph receptor B2 antibody; EPH tyrosine kinase 3 antibody; EPH-like kinase 5 antibody; EPHB2 antibody; EPHB2_HUMAN antibody; Ephrin type B receptor 2 antibody; Ephrin type-B receptor 2 antibody; EPHT 3 antibody; ERK antibody; ETECK antibody; hEK5 antibody; Nuk antibody; Prkm 5 antibody; Receptor protein tyrosine kinase HEK 5 antibody; Renal carcinoma antigen NY-REN-47 antibody; Sek 3 antibody; Tyro 5 antibody; Tyrosine protein kinase receptor CEK 5 antibody; Tyrosine protein kinase receptor EPH 3 antibody; Tyrosine protein kinase receptor QEK 5 antibody; Tyrosine-protein kinase receptor EPH-3 antibody; Tyrosine-protein kinase TYRO5 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P29323

Immunogen:Peptide sequence around aa.896~900 (L-S-S-G-I) derived Human from EPHB2.

Raised in:Rabbit

Species Reactivity:Human, Mouse, Rat

Tested Applications:ELISA, WB; WB:1:500-1:1000

Background:

Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. Beside axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses.

Kalo MS, Yu HH, Pasquale EB. J Biol Chem 276, 38940-8 (2001)

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Conjugate:Non-conjugated

Buffer:Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:EPHB2

Research Areas:Neuroscience?Cancer?Cardiovascular;Signal transduction