EEA1 rabbit pAb

SKU: ES3758

Size: 100μL

Source:Rabbit

Applications:WB;ELISA

Reactivity:Human;Mouse

Dilution:Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.

Immunogen:The antiserum was produced against synthesized peptide derived from human EEA1. AA range:205-254

Storage_stability:-20°C/1 year

Clonality:Polyclonal

Isotype:IgG

Concentration:1 mg/ml

Observed_band(KD):162kD

Human_gene_id:8411

Human_swiss_prot_no:Q15075

Subcellular_location:Cytoplasm. Early endosome membrane; Peripheral membrane protein.

Other_name:EEA1; ZFYVE2; Early endosome antigen 1; Endosome-associated protein p162; Zinc finger FYVE domain-containing protein 2

Background:disease:Antibodies against EEA1 are found in sera from patients with subacute cutaneous lupus erythematosus and other autoimmune diseases.,domain:The FYVE-type zinc finger domain mediates interactions with phosphatidylinositol 3-phosphate.,function:Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking.,similarity:Contains 1 C2H2-type zinc finger.,similarity:Contains 1 FYVE-type zinc finger.,subunit:Homodimer. Binds STX6. Binds RAB5A, RAB5B, RAB5C and RAB22A that have been activated by GTP-binding.,