E-Selectin rabbit pAb

SKU: ES8463

Size: 100μL

Source:Rabbit

Applications:WB;IHC;IF;ELISA

Reactivity:Human;Rat;Mouse;

Dilution:IHC-p: 100-300.WB 1:500-2000, ELISA 1:10000-20000

Immunogen:The antiserum was produced against synthesized peptide derived from the N-terminal region of human SELE. AA range:100-150

Storage_stability:-20°C/1 year

Clonality:Polyclonal

Isotype:IgG

Concentration:1 mg/ml

Observed_band(KD):66kD

Human_gene_id:6401

Human_swiss_prot_no:P16581

Subcellular_location:Cell membrane ; Single-pass type I membrane protein.

Other_name:selectin E

Background:The protein encoded by this gene is found in cytokine-stimulated endothelial cells and is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. It exhibits structural features such as the presence of lectin- and EGF-like domains followed by short consensus repeat (SCR) domains that contain 6 conserved cysteine residues. These proteins are part of the selectin family of cell adhesion molecules. Adhesion molecules participate in the interaction between leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis. [provided by RefSeq, Jul 2008],