DTX1 antibody , Cat. # FNab02553

SKU: FNab02553

Size:100ug

Purification:Immunogen affinity purified

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Rabbit

Clonality:polyclonal

Clone ID:

Isotype:IgG

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)

Background:Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity(By similarity). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB(Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T-cell development, suggesting that it can antagonize NOTCH1.

Immunogen:deltex homolog 1(Drosophila)

Synonyms:

Observed MW:67-72,58-63 kDa

Uniprot ID:Q86Y01

Reactivity:Human, Mouse, Rat

Tested Application:ELISA, IF, IHC

Recommended dilution:IHC: 1:20-1:200; IF: 1:20-1:200

Gene ID:1840

Research Area:Signal Transduction, Metabolism, Cardiovascular, Immunology, Developmental biology