DR5 Rabbit Polyclonal Antibody

SKU: BT-AP09336

Size:100μL

Background:The protein encoded by this gene is a member of the TNF-receptor superfamily| and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L)| and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD| a death domain containing adaptor protein| is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene.

Research_area:Signal transduction; Cardiovascular; Cancer

Target_protein:TNFRSF10B

applications:WB, ELISA

Reactivity:Human, Rat, Mouse

Clonality:Polyclonal

Clone ID:

Host:Rabbit

Isotype:IgG

Gene Symbol/ Name:DR5

Immunogen:The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage:-20°C for 1 year

Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration:1 mg/ml

Molecular weight(Da):48400

UniProt accession:Human: O14763; Mouse: Q9QZM4

Synonyms:DR5; Tumor necrosis factor receptor superfamily member 10B; Death receptor 5; TNF-related apoptosis-inducing ligand receptor 2; TRAIL receptor 2; TRAIL-R2; CD antigen CD262

GeneID:Human: 8795; Mouse: 21933