DNMT3B Antibody - Cat. #: CSB-PA883358HA01HU

SKU: CSB-PA883358HA01HU

Size :50ug

Clone Number:

Aliases:Cytosine 5methyltransferase 3B antibody; DNA antibody; DNA (cytosine 5) methyltransferase 3 beta antibody; DNA (cytosine 5)-methyltransferase 3B antibody; DNA (cytosine-5)-methyltransferase 3B antibody; DNA methyltransferase HsaIIIB antibody; DNA MTase HsaIIIB antibody; DNM3B_HUMAN antibody; Dnmt3b antibody; EC 2.1.1.37 antibody; ICF antibody; ICF1 antibody; M.HsaIIIB antibody; MGC124407 antibody; RP23-89H14.3 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q9UBC3

Immunogen:Recombinant Human DNA (cytosine-5)-methyltransferase 3B protein (1-100AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, WB, IHC, IF; Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200

Background:Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing (By similarity). In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs. Function as transcriptional corepressor by associating with ZHX1.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Non-conjugated

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:DNMT3B

Research Areas:Epigenetics and Nuclear Signaling