DMAP1 Antibody, Biotin conjugated - Cat. #: CSB-PA873611LD01HU

SKU: CSB-PA873611LD01HU

Size :50ug

Clone Number:

Aliases:DMAP1 antibody; KIAA1425DNA methyltransferase 1-associated protein 1 antibody; DNMAP1 antibody; DNMT1-associated protein 1 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q9NPF5

Immunogen:Recombinant Human DNA methyltransferase 1-associated protein 1 protein (250-300AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA

Background:Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX-mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Participates in the nuclear localization of URI1 and increases its transcriptional corepressor activity.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Biotin

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:DMAP1

Research Areas:Epigenetics and Nuclear Signaling