DFFA Monoclonal Antibody

SKU: BT-MCA3777

Size:100μL

Background:Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Research_area:Cell Biology

Target_protein:DFFA

applications:FCM

Reactivity:

Clonality:Monoclonal

Clone ID:2B10C8

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:DFFA

Immunogen:Purified recombinant fragment of human DFFA (AA: 179-331) expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Purified antibody in PBS with 0.05% sodium azide

Concentration:

Molecular weight(Da):36.5kDa

UniProt accession:O00273

Synonyms:DFF1, ICAD, DFF-45

GeneID:1676