DDR1 antibody , Cat. # FNab10051

SKU: FNab10051

Size:100ug

Purification:Immunogen affinity purified

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Rabbit

Clonality:polyclonal

Clone ID:

Isotype:IgG

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)

Background:Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing(By similarity). Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11.

Immunogen:discoidin domain receptor tyrosine kinase 1

Synonyms:CAK, EDDR1, NEP, NTRK4, PTK3A, RTK6, TRKE

Observed MW:101 kDa

Uniprot ID:Q08345

Reactivity:Human,Rat

Tested Application:ELISA, WB, IHC

Recommended dilution:WB: 1:500-1:2000; IHC: 1:50-1:500

Gene ID:780

Research Area:Immunology, Cardiovascular, Metabolism, Signal Transduction