DDB1 Antibody - Cat. #: CSB-PA056628

SKU: CSB-PA056628

Size :50ul

Clone Number:

Aliases:Damage specific DNA binding protein 1 antibody; Damage-specific DNA-binding protein 1 antibody; DDB 1 antibody; DDB p127 subunit antibody; Ddb1 antibody; DDB1_HUMAN antibody; DDBa antibody; DNA damage binding protein 1 antibody; DNA damage-binding protein 1 antibody; DNA damage-binding protein a antibody; HBV X-associated protein 1 antibody; UV damaged DNA binding factor antibody; UV damaged DNA binding protein 1 antibody; UV DDB 1 antibody; UV DDB1 antibody; UV-damaged DNA-binding factor antibody; UV-damaged DNA-binding protein 1 antibody; UV-DDB 1 antibody; X associated protein 1 antibody; XAP 1 antibody; XAP-1 antibody; XAP1 antibody; Xeroderma pigmentosum group E complementing protein antibody; Xeroderma pigmentosum group E-complementing protein antibody; XPCe antibody; XPE antibody; XPE BF antibody; XPE binding factor antibody; XPE-BF antibody; XPE-binding factor antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q16531

Immunogen:Synthetic peptide of Human DDB1

Raised in:Rabbit

Species Reactivity:Human, Mouse, Rat

Tested Applications:ELISA, WB, IHC; ELISA:1:500-1:5000, WB:1:200-1:1000, IHC:1:10-1:100

Background:The protein encoded by this gene is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex while another protein (p48) forms the small subunit. This protein complex functions in nucleotide-excision repair and binds to DNA following UV damage. Defective activity of this complex causes the repair defect in patients with xeroderma pigmentosum complementation group E (XPE) - an autosomal recessive disorder characterized by photosensitivity and early onset of carcinomas. However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients. The protein encoded by this gene also functions as an adaptor molecule for the cullin 4 (CUL4) ubiquitin E3 ligase complex by facilitating the binding of substrates to this complex and the ubiquitination of proteins.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen affinity purification

Conjugate:Non-conjugated

Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:DDB1

Research Areas:Isotype/Loading Controls;Epigenetics and Nuclear Signaling?Neuroscience?Cancer;Metabolism;Signal transduction