DCLK2 Monoclonal Antibody

SKU: BT-MCA2093

Size:100μL

Background:This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. Mouse studies show that the DCX gene, another family member, and this gene share function in the establishment of hippocampal organization and that their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants have been identified.

Research_area:Signal Transduction

Target_protein:DCLK2

applications:IHC, FCM

Reactivity:Human

Clonality:Monoclonal

Clone ID:3H1G4

Host:Mouse

Isotype:Mouse IgG2a

Gene Symbol/ Name:DCLK2

Immunogen:Purified recombinant fragment of human DCLK2 (AA: 652-766) expressed in mammalian.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Purified antibody in PBS with 0.05% sodium azide

Concentration:

Molecular weight(Da):83.6kDa

UniProt accession:Q8N568

Synonyms:CL2, DCK2, CLIK2, DCDC3, CLICK2, DCDC3B, DCAMKL2, CLICK-II

GeneID:166614