DAAM1 rabbit pAb

SKU: ES8614

Size: 100μL

Source:Rabbit

Applications:WB;ELISA

Reactivity:Human;Mouse

Dilution:WB 1:500-2000, ELISA 1:10000-20000

Immunogen:Synthetic peptide from human protein at AA range: 400-500

Storage_stability:-20°C/1 year

Clonality:Polyclonal

Isotype:IgG

Concentration:1 mg/ml

Observed_band(KD):123kD

Human_gene_id:23002

Human_swiss_prot_no:Q9Y4D1

Subcellular_location:Cytoplasm . Cytoplasm, cytoskeleton, cilium basal body . Perinuclear.

Other_name:Disheveled-associated activator of morphogenesis 1

Background:Cell motility, adhesion, cytokinesis, and other functions of the cell cortex are mediated by reorganization of the actin cytoskeleton and several formin homology (FH) proteins have been associated with these processes. The protein encoded by this gene contains two FH domains and belongs to a novel FH protein subfamily implicated in cell polarity. A key regulator of cytoskeletal architecture, the small GTPase Rho, is activated during development by Wnt/Fz signaling to control cell polarity and movement. The protein encoded by this gene is thought to function as a scaffolding protein for the Wnt-induced assembly of a disheveled (Dvl)-Rho complex. This protein also promotes the nucleation and elongation of new actin filaments and regulates cell growth through the stabilization of microtubules. Alternative splicing results in multiple transcript variants encoding distinct