Cystatin C (7F11) Mouse mAb

SKU: EM1275

Size: 100μL

Source:Mouse

Applications:WB, IHC, ELISA

Reactivity:Human

Dilution:WB 1:1,000-2,000 IHC 1:100-200 ELISA 1:10,000-20,000

Immunogen:Recombinant Protein

Storage_stability:PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

Clonality:Monoclonal

Isotype:IgG1

Concentration:1mg/mL

Observed_band(KD):14kDa

Human_gene_id:1471

Human_swiss_prot_no:P01034

Subcellular_location:Secreted

Other_name:AD8, Cystatin3, Gamma trace, HCCAA

Background:Cystatin C is a 13-kDa inhibitor of cysteine proteinases which is secreted by all cell types and is completely cleared from the organism through glomerular filtration, shown to be an early and sensitive biomarker of renal dysfunction. A mutation in Cystatin C has been associated with amyloid angiopathy. Expression of this protein in vascular wall smooth muscle cells is severely reduced in both atherosclerotic and aneurysmal aortic lesions, establishing its role in vascular disease. In addition, this protein has been shown to have an antimicrobial function, inhibiting the replication of herpes simplex virus.