CYP3A4 Monoclonal Antibody

SKU: BT-MCA4652

Size:100μL

Background:This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified.

Research_area:Cardiovascular

Target_protein:CYP3A4

applications:IHC, ICC, FCM

Reactivity:Human

Clonality:Monoclonal

Clone ID:3H8

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:CYP3A4

Immunogen:Purified recombinant fragment of human CYP3A4 expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Purified antibody in PBS with 0.05% sodium azide

Concentration:

Molecular weight(Da):57.3kDa

UniProt accession:P08684

Synonyms:HLP, CP33, CP34, CYP3A, NF-25, CYP3A3, P450C3, CYPIIIA3, CYPIIIA4, P450PCN1

GeneID:1576