COPS3 Antibody - Cat. #: CSB-PA799923

SKU: CSB-PA799923

Size :100ul

Clone Number:

Aliases:Constitutive photomorphogenic homolog subunit 3 antibody; COP 9 (constitutive photomorphogenic) subunit 3 antibody; COP 9 complex homolog subunit 3 antibody; COP 9 complex S3 antibody; COP 9 complex subunit 3 antibody; COP 9 constitutive photomorphogenic homolog subunit 3 antibody; COP 9 homolog antibody; COP 9 signalosome complex subunit 3 antibody; COP 9 signalosome subunit 3 antibody; COP 9 subunit 3 antibody; COP9 (constitutive photomorphogenic) subunit 3 antibody; COP9 complex homolog subunit 3 antibody; COP9 complex S3 antibody; COP9 complex subunit 3 antibody; COP9 constitutive photomorphogenic homolog subunit 3 antibody; COP9 homolog antibody; COP9 signalosome complex subunit 3 antibody; COP9 signalosome subunit 3 antibody; COP9 subunit 3 antibody; COPS 3 antibody; cops3 antibody; CSN 3 antibody; CSN3 antibody; CSN3_HUMAN antibody; JAB 1 containing signalosome subunit 3 antibody; JAB1 containing signalosome subunit 3 antibody; JAB1-containing signalosome subunit 3 antibody; SGN 3 antibody; SGN3 antibody; Signalosome subunit 3 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q9UNS2

Immunogen:Synthesized peptide derived from Human JAB1.

Raised in:Rabbit

Species Reactivity:Human, Mouse, Rat

Tested Applications:ELISA, WB, IF; WB:1:500-1:3000, IF:1:100-1:500

Background:Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

George Z. Rassidakis, Clin. Cancer Res., Mar 2003; 9: 1121.
Ricardo V. Lloyd, Am. J. Pathol., Mar 2002; 160: 1171.
Shu Xiao, PNAS, Oct 2006; 103: 16448 - 16453.
Alex Kudrin, J. Biol. Chem., Oct 2006; 281: 29641 - 29651.

Clonality:Polyclonal

Isotype:IgG

Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:COPS3

Research Areas:Neuroscience;Cell biology