COL4A2 Antibody - Cat. #: CSB-PA11947A0Rb

SKU: CSB-PA11947A0Rb

Size :50ug

Clone Number:

Aliases:Canstatin antibody; CO4A2_HUMAN antibody; COL4A 2 antibody; Col4a2 antibody; Collagen alpha 2(IV) chain antibody; Collagen; type IV; alpha 2 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P08572

Immunogen:Recombinant Human Collagen alpha-2(IV) chain protein (1493-1712AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background:Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a \\\'chicken-wire\\\' meshwork together with laminins, proteoglycans and entactin/nidogen. Canstatin, a cleavage product corresponding to the collagen alpha 2(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity. It inhibits proliferation and migration of endothelial cells, reduces mitochondrial membrane potential, and induces apoptosis. Specifically induces Fas-dependent apoptosis and activates procaspase-8 and -9 activity. Ligand for alphavbeta3 and alphavbeta5 integrins.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Non-conjugated

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:COL4A2

Research Areas:Cardiovascular; Signal transduction