CLU Antibody - Cat. #: CSB-PA06029A0Rb

SKU: CSB-PA06029A0Rb

Size :50ug

Clone Number:

Aliases:40 antibody; AAG 4 antibody; AAG4 antibody; Aging associated protein 4 antibody; Aging-associated gene 4 protein antibody; AI893575 antibody; APO J antibody; Apo-J antibody; APOJ antibody; ApoJalpha antibody; ApoJbeta antibody; Apolipoprotein J antibody; ApolipoproteinJ antibody; CLI antibody; CLU antibody; CLU1 antibody; CLU2 antibody; CLUS_HUMAN antibody; Clusterin alpha chain antibody; Clusterin antibody; Clusterin beta chain antibody; Complement associated protein SP 40 40 antibody; Complement associated protein SP 40 antibody; Complement associated protein SP40 antibody; Complement cytolysis inhibitor a chain antibody; Complement cytolysis inhibitor antibody; Complement cytolysis inhibitor b chain antibody; Complement lysis inhibitor antibody; Complement-associated protein SP-40 antibody; D14Ucla3 antibody; Dimeric acid glycoprotein antibody; Glycoprotein 80 antibody; Glycoprotein III antibody; GP80 antibody; Ku70-binding protein 1 antibody; KUB 1 antibody; KUB1 antibody; MGC24903 antibody; NA1/NA2 antibody; RATTRPM2B antibody; SGP 2 antibody; SGP2 antibody; SP 40 antibody; SP40 antibody; Sugp-2 antibody; Sulfated glycoprotein 2 antibody; Testosterone repressed prostate message 2 antibody; Testosterone-repressed prostate message 2 antibody; TRPM 2 antibody; TRPM-2 antibody; TRPM2 antibody; TRPM2B antibody; Trpmb antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P10909

Immunogen:Recombinant Human Clusterin protein (23-224AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, IHC, IF; Recommended dilution: IHC:1:200-1:500, IF:1:50-1:200

Background:Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. Secreted isoform 1 protects cells against apoptosis and against cytolysis by complement. Intracellular isoforms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Nuclear isoforms promote apoptosis. Mitochondrial isoforms suppress BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis. Plays a role in the regulation of cell proliferation.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Non-conjugated

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:CLU

Research Areas:Cancer; Cardiovascular; Immunology; Metabolism; Signal transduction