CLSPN antibody , Cat. # FNab01775

SKU: FNab01775

Size:100ug

Purification:Immunogen affinity purified

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Rabbit

Clonality:polyclonal

Clone ID:

Isotype:IgG

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)

Background:Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation. Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins. Can also bind specifically to branched DNA structures and may associate with S-phase chromatin following formation of the pre-replication complex(pre-RC). This may indicate a role for this protein as a sensor which monitors the integrity of DNA replication forks.

Immunogen:claspin homolog(Xenopus laevis)

Synonyms:

Observed MW:240 kDa

Uniprot ID:Q9HAW4

Reactivity:Human

Tested Application:ELISA, WB, IF, IP

Recommended dilution:WB: 1:200-1:1000; IP: 1:500-1:2000; IF: 1:20-1:200

Gene ID:63967

Research Area: