Cleaved-Caspase-6 p18 (D162) rabbit pAb

SKU: ES1003

Size: 100μL

Source:Rabbit

Applications:WB;IHC;IF;ELISA

Reactivity:Mouse;Rat

Dilution:Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.

Immunogen:The antiserum was produced against synthesized peptide derived from mouse Caspase 6. AA range:144-193

Storage_stability:-20°C/1 year

Clonality:Polyclonal

Isotype:IgG

Concentration:1 mg/ml

Observed_band(KD):28+35kD

Human_gene_id:

Human_swiss_prot_no:

Subcellular_location:

Other_name:CASP6; MCH2; Caspase-6; CASP-6; Apoptotic protease Mch-2

Background:CASP6 encodes a member of the cysteine-aspartic acid protease (caspase) family of enzymes. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic acid residues to produce two subunits, large and small, that dimerize to form the active enzyme.Caspase 6 is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of CASP6 results in multiple transcript variants that encode different isoforms.