CHRNB3 Monoclonal Antibody

SKU: BT-MCA3521

Size:100μL

Background:The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are (hetero)pentamers composed of homologous subunits. The subunits that make up the muscle and neuronal forms of nAChRs are encoded by separate genes and have different primary structure. There are several subtypes of neuronal nAChRs that vary based on which homologous subunits are arranged around the central channel. They are classified as alpha-subunits if, like muscle alpha-1 (MIM 100690), they have a pair of adjacent cysteines as part of the presumed acetylcholine binding site. Subunits lacking these cysteine residues are classified as beta-subunits (Groot Kormelink and Luyten, 1997 [PubMed 9009220]). Elliott et al. (1996) [PubMed 8906617] stated that the proposed structure for each subunit is a conserved N-terminal extracellular domain followed by 3 conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region.

Research_area:Neuroscience

Target_protein:CHRNB3

applications:FCM

Reactivity:Human

Clonality:Monoclonal

Clone ID:7C9F12

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:CHRNB3

Immunogen:Purified recombinant fragment of human CHRNB3 (AA: extra 25-232) expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Purified antibody in PBS with 0.05% sodium azide

Concentration:

Molecular weight(Da):52.7kDa

UniProt accession:Q05901

Synonyms:

GeneID:1142