CHAC1 Antibody, Biotin conjugated - Cat. #: CSB-PA883606LD01HU

SKU: CSB-PA883606LD01HU

Size :50ug

Clone Number:

Aliases:Blocks Notch protein antibody; Botch antibody; Cation transport regulator like protein 1 antibody; Cation transport regulator-like protein 1 antibody; ChaC antibody; ChaC cation transport regulator homolog 1 antibody; ChaC cation transport regulator like 1 antibody; chac1 antibody; CHAC1_HUMAN antibody; Gamma GCT acting on glutathione homolog 1 antibody; Gamma-GCG 1 antibody; Glutathione-specific gamma-glutamylcyclotransferase 1 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q9BUX1

Immunogen:Recombinant Human Glutathione-specific gamma-glutamylcyclotransferase 1 protein (43-264AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA

Background:Catalyzes the cleavage glutathione into 5-oxoproline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. Glutathione depletion is an important factor for apoptosis initiation and execution (PubMed:23070364). Acts as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade (PubMed:19109178). Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos (PubMed:22445366).

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Biotin

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:CHAC1

Research Areas:Cell biology