CDKN2A Antibody - Cat. #: CSB-PA445592

SKU: CSB-PA445592

Size :50ul

Clone Number:

Aliases:CDKN2A antibody; CDKN2 antibody; MTS1 antibody; Cyclin-dependent kinase inhibitor 2A antibody; Cyclin-dependent kinase 4 inhibitor A antibody; CDK4I antibody; Multiple tumor suppressor 1 antibody; MTS-1 antibody; p16-INK4a antibody; p16-INK4 antibody; p16INK4A antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P42771

Immunogen:Synthetic peptide of Human CDKN2A

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, IHC; ELISA:1:1000-1:5000, IHC:1:50-1:200

Background:This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen affinity purification

Conjugate:Non-conjugated

Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:CDKN2A

Research Areas:Epigenetics and Nuclear Signaling;Cancer;Cell biology