CD68 Mouse mAb

SKU: EM1050

Size: 100μL

Source:Mouse

Applications:IHC

Reactivity:Human, Rat, Mouse

Dilution:IHC 1:200

Immunogen:Synthetic Peptide

Storage_stability:PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

Clonality:Monoclonal

Isotype:IgG1

Concentration:1mg/mL

Observed_band(KD):37kDa

Human_gene_id:968

Human_swiss_prot_no:P34810

Subcellular_location:Cell membrane and Endosome membrane. Lysosome membrane

Other_name:CD68 molecule, GP110, Macrosialin, SCARD1

Background:The CD68 antigen is a 37kD transmembrane protein that is post-translationally glycosylated to give a protein of 87-115kD. CD68 is specifically expressed by tissue macrophages, Langerhans cells and at low levels by dendritic cells. It could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. It binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin bearing substrates or other cells.