CD253 Monoclonal Antibody

SKU: BT-MCA2476

Size:100μL

Background:The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Research_area:Others

Target_protein:CD253

applications:FCM

Reactivity:Human

Clonality:Monoclonal

Clone ID:6D4C6

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:CD253

Immunogen:Purified recombinant fragment of human CD253 (AA: extra 39-281) expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Purified antibody in PBS with 0.05% sodium azide

Concentration:

Molecular weight(Da):32.5kDa

UniProt accession:P50591

Synonyms:TNFSF10, TL2, APO2L, TRAIL, Apo-2L, TNLG6A

GeneID:8743