CBFA2T2 Polyclonal Antibody

SKU: E-AB-19075

Size: 200μL

Storage: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping: The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date: 12 months

Category ID_II: Primary Antibodies

Category ID_III: Polyclonal Antibodies

Abbreviation: CBFA2T2

Target Synonym: AML1 MTG8;cbfa2t2;Core binding factor runt domain alpha subunit 2 translocated to 2;core-binding factor; runt domain; alpha subunit 2;DKFZp313F2116;EHT;ETO homolog on chromosome 20;ETO homologous on chromosome 20;MTG 8 like protein;MTG 8 related protein 1;MTG8 like protein;MTG8 related protein 1;MTG8-like protein;MTG8-related protein 1;MTG8R;MTGR 1;Myeloid translocation gene related protein 1;Myeloid translocation related protein 1;Myeloid translocation-related protein 1;p85;Protein CBFA2T2;ZMYND 3;ZMYND3

Research Areas: Tags;Cell Markers

Conjugation: Unconjugated

Host: Rabbit

Species reactivity: Human;Mouse

Application: WB

Isotype: IgG

Clonality: Polyclonal

Clone NO.:

UNIProt ID: O43439

Accession:

Background: In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described.

Concentration: 1.26 mg/mL

Immunogen: Fusion protein of human CBFA2T2

Buffer: PBS with 0.05% NaN3 and 40% Glycerol,pH7.4

Purification method: Antigen affinity purification

Dilution: WB 1:1000-1:5000

Calculated MW: 67 kDa

ObservedMW: Refer to figures