CASP3 Monoclonal Antibody

SKU: BT-MCA2580

Size:100μL

Background:This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.

Research_area:Cell Biology

Target_protein:CASP3

applications:WB, FCM

Reactivity:Human

Clonality:Monoclonal

Clone ID:3D4D7

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:CASP3

Immunogen:Purified recombinant fragment of human CASP3 (AA: 29-175) expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Purified antibody in PBS with 0.05% sodium azide

Concentration:

Molecular weight(Da):31.6kDa

UniProt accession:P42574

Synonyms:CPP32, SCA-1, CPP32B

GeneID:836