C4BPB antibody , Cat. # FNab01114

SKU: FNab01114

Size:100ug

Purification:Immunogen affinity purified

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Rabbit

Clonality:polyclonal

Clone ID:

Isotype:IgG

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20? for 12 months (Avoid repeated freeze / thaw cycles.)

Background:This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. A single, unique beta-chain encoded by this gene assembles with seven identical alpha-chains into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. C4b-binding protein has a regulatory role in the coagulation system also, mediated through the beta-chain binding of protein S, a vitamin K-dependent protein that serves as a cofactor of activated protein C. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Alternative splicing gives rise to multiple transcript variants.

Immunogen:complement component 4 binding protein, beta

Synonyms:C4b binding protein beta chain, C4BP, C4BPB

Observed MW:40-45 kDa

Uniprot ID:P20851

Reactivity:Human, Mouse, Rat

Tested Application:ELISA, IHC, WB, IF

Recommended dilution:WB: 1:500 - 1:2000; IHC: 1:50 - 1:100; IF: 1:50 - 1:100

Gene ID:725

Research Area:Immunology