Bovine Peptidoglycan Recognition Protein 1, PGLYRP1 ELISA Kit

SKU: E2303Bo

Size:96 Tests-1 Kit

Background:Innate immunity protein that plays several important functions in antimicrobial and antitumor defense systems. Acts as a pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria and thus provides bactericidal activity (PubMed: 11880375, PubMed: 16394004). Forms an equimolar complex with heat shock protein HSPA1A and induces programmed cell death through apoptosis and necroptosis in tumor cell lines by activating the TNFR1 receptor on the target cell membrane. In addition, acts in complex with the Ca(2+)-binding protein S100A4 as a chemoattractant able to induce lymphocyte movement. Mechanistically, this complex acts as a ligand of the chemotactic receptors CCR5 and CXCR3 which are present on the cells of the immune system. Promotes also the activation of lymphocytes that become able to kill virus-infected cells as well as tumor cells by modulating the spectrum of their target-cell specificity. Induction of cytotoxicity on monocyte surface requires interaction with TREM1 receptor (By similarity).

Research_area:Others

Applications:ELISA

Target_protein:PGLYRP1

Reactivity:Bovine

Assay type:Sandwich

Sensitivity:0.091ng/ml

Detection range:0.2-60ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Peptidoglycan Recognition Protein 1

Species:Bovine

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q8SPP7

MASS(Da):21,063

GeneID:282305

Synonyms:OBP;Oligosaccharide-binding protein;Peptidoglycan recognition protein 1;Peptidoglycan recognition protein short;PGLYRP 1;PGLYRP1;PGRP-S

Gene names:PGLYRP1

Standard solution:64ng/ml