Bovine Histidine-proline-rich glycoprotein,HPRG ELISA KIT

SKU: E0092Bo

Size:96Tests

Background:Plasma glycoprotein that binds a number of ligands such as heme, heparin, heparan sulfate, thrombospondin, plasminogen, and divalent metal ions. Inhibits rosette formation. Acts as an adapter protein and implicated in regulating many processes such as immune complex and pathogen clearance, cell adhesion, angiogenesis, coagulation and fibrinolysis. Mediates clearance of necrotic cells through enhancing the phagocytosis of necrotic cells in a heparan sulfate-dependent pathway. This process can be regulated by the presence of certain HRG ligands such as heparin and zinc ions. Binds to IgG subclasses of immunoglobins containing kappa and lambda light chains with different affinities regulating their clearance and inhibiting the formation of insoluble immune complexes. Tethers plasminogen to the cell surface. Binds T-cells and alters the cell morphology. Modulates angiogenesis by blocking the CD6-mediated antiangiongenic effect of thrombospondins, THBS1 and THBS2 (By similarity). {ECO:0000250}.

Research_area:

Applications:ELISA

Target_protein:HRG

Reactivity:Bovine

Assay type:Sandwich

Sensitivity:0.25ng/ml

Detection range:0.5-32ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Histidine-proline-rich glycoprotein

Species:Bovine

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P33433

MASS(Da):44471

GeneID:

Synonyms:HRG

Gene names:HRG

Standard solution:64ng/ml