Bovine Breast cancer type 1 susceptibility protein homolog,BRCA1 ELISA KIT

SKU: E0160Bo

Size:96Tests

Background:E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Required for FANCD2 targeting to sites of DNA damage. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation. Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks. Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8. Acts as a transcriptional activator. {ECO:0000250|UniProtKB:P38398}.

Research_area:

Applications:ELISA

Target_protein:BRCA1

Reactivity:Bovine

Assay type:Sandwich

Sensitivity:0.32ng/ml

Detection range:0.75-48ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Breast cancer susceptibility protein 1

Species:Bovine

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q864U1

MASS(Da):206279

GeneID:353120

Synonyms:BRCA1

Gene names:BRCA1

Standard solution:96ng/ml